The immune responses of HLA-A*0201 restricted SARS-CoV S peptide-specific CD8+ T cells are augmented in varying degrees by CpG ODN, PolyI:C and R848
Identifieur interne : 002027 ( Main/Exploration ); précédent : 002026; suivant : 002028The immune responses of HLA-A*0201 restricted SARS-CoV S peptide-specific CD8+ T cells are augmented in varying degrees by CpG ODN, PolyI:C and R848
Auteurs : Kai Zhao ; Hui Wang ; Changyou WuSource :
- Vaccine [ 0264-410X ] ; 2011.
Descripteurs français
- KwdFr :
- Adjuvants immunologiques (administration et posologie), Animaux, Antigène HLA-A2 (immunologie), Antigènes CD (analyse), Cytométrie en flux, Humains, Imidazoles (administration et posologie), Interféron gamma (biosynthèse), Lymphocytes T CD8+ (), Lymphocytes T CD8+ (immunologie), Oligodésoxyribonucléotides (administration et posologie), Poly I-C (administration et posologie), Rappel de vaccin, Souris, Souris transgéniques, Test ELISA, Test ELISpot, Vaccination (), Vaccins antiviraux (administration et posologie), Vaccins antiviraux (immunologie), Virus du SRAS (immunologie), Épitopes (immunologie).
- MESH :
- administration et posologie : Adjuvants immunologiques, Imidazoles, Oligodésoxyribonucléotides, Poly I-C, Vaccins antiviraux.
- analyse : Antigènes CD.
- biosynthèse : Interféron gamma.
- immunologie : Antigène HLA-A2, Lymphocytes T CD8+, Vaccins antiviraux, Virus du SRAS, Épitopes.
- Animaux, Cytométrie en flux, Humains, Lymphocytes T CD8+, Rappel de vaccin, Souris, Souris transgéniques, Test ELISA, Test ELISpot, Vaccination.
English descriptors
- KwdEn :
- Adjuvants, Immunologic (administration & dosage), Animals, Antigens, CD (analysis), CD8-Positive T-Lymphocytes (chemistry), CD8-Positive T-Lymphocytes (immunology), Enzyme-Linked Immunosorbent Assay, Enzyme-Linked Immunospot Assay, Epitopes (immunology), Flow Cytometry, HLA-A2 Antigen (immunology), Humans, Imidazoles (administration & dosage), Immunization, Secondary, Interferon-gamma (biosynthesis), Mice, Mice, Transgenic, Oligodeoxyribonucleotides (administration & dosage), Poly I-C (administration & dosage), SARS Virus (immunology), Vaccination (methods), Viral Vaccines (administration & dosage), Viral Vaccines (immunology).
- MESH :
- chemical , administration & dosage : Adjuvants, Immunologic, Imidazoles, Oligodeoxyribonucleotides, Poly I-C, Viral Vaccines.
- chemical , analysis : Antigens, CD.
- chemical , biosynthesis : Interferon-gamma.
- chemistry : CD8-Positive T-Lymphocytes.
- immunology : CD8-Positive T-Lymphocytes, Epitopes, HLA-A2 Antigen, SARS Virus, Viral Vaccines.
- methods : Vaccination.
- Animals, Enzyme-Linked Immunosorbent Assay, Enzyme-Linked Immunospot Assay, Flow Cytometry, Humans, Immunization, Secondary, Mice, Mice, Transgenic.
Abstract
The induction of antigen specific memory CD8+ T cells in vivo is very important to new vaccines against infectious diseases. In the present study, we aimed to evaluate the immune responses of peptide-specific CD8+ T cells induced by HLA-A*0201 restricted severe acute respiratory syndrome-associated coronavirus (SARS-CoV) S epitopes plus CpG oligodeoxynucleotide (CpG ODN), PolyI:C and R848 as adjuvants. Furthermore, the generation, distribution and phenotype of long-lasting peptide-specific memory CD8+ T cells were assessed by ELISA, ELISPOT and flow cytometry. Our results showed that antigen specific CD8+ T cells were elicited by HLA-A*0201 restricted SARS-CoV S epitopes. Furthermore, the frequency of peptide-specific CD8+ T cells was dramatically increased after both prime and boost immunization with peptides plus CpG ODN, whereas slight enhancements were induced following boost vaccination with peptides plus PolyI:C or R848. SARS-CoV S peptide-specific IFN-γ+CD8+ T cells were distributed throughout the lymphoid and non-lymphoid tissues. Results also demonstrated that the HLA-A*0201 restricted peptide-specific CD8+ T cells induced by peptides plus CpG ODN carried a memory cell phenotype with CD45RB+ and CD62L− and possessed long-term survival ability in vivo. Taken together, our results implied that HLA-A*0201 restricted SARS-CoV S epitopes plus CpG ODN might be the superior candidates for SARS vaccine.
Url:
DOI: 10.1016/j.vaccine.2011.06.100
PubMed: 21745520
PubMed Central: 7115397
Affiliations:
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Le document en format XML
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type="eISSN">1873-2518</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adjuvants, Immunologic (administration & dosage)</term><term>Animals</term><term>Antigens, CD (analysis)</term><term>CD8-Positive T-Lymphocytes (chemistry)</term><term>CD8-Positive T-Lymphocytes (immunology)</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Enzyme-Linked Immunospot Assay</term><term>Epitopes (immunology)</term><term>Flow Cytometry</term><term>HLA-A2 Antigen (immunology)</term><term>Humans</term><term>Imidazoles (administration & dosage)</term><term>Immunization, Secondary</term><term>Interferon-gamma (biosynthesis)</term><term>Mice</term><term>Mice, Transgenic</term><term>Oligodeoxyribonucleotides (administration & dosage)</term><term>Poly I-C (administration & dosage)</term><term>SARS Virus (immunology)</term><term>Vaccination (methods)</term><term>Viral Vaccines (administration & dosage)</term><term>Viral Vaccines (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adjuvants immunologiques (administration et posologie)</term><term>Animaux</term><term>Antigène HLA-A2 (immunologie)</term><term>Antigènes CD (analyse)</term><term>Cytométrie en flux</term><term>Humains</term><term>Imidazoles (administration et posologie)</term><term>Interféron gamma (biosynthèse)</term><term>Lymphocytes T CD8+ ()</term><term>Lymphocytes T CD8+ (immunologie)</term><term>Oligodésoxyribonucléotides (administration et posologie)</term><term>Poly I-C (administration et posologie)</term><term>Rappel de vaccin</term><term>Souris</term><term>Souris transgéniques</term><term>Test ELISA</term><term>Test ELISpot</term><term>Vaccination ()</term><term>Vaccins antiviraux (administration et posologie)</term><term>Vaccins antiviraux (immunologie)</term><term>Virus du SRAS (immunologie)</term><term>Épitopes (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Adjuvants, Immunologic</term><term>Imidazoles</term><term>Oligodeoxyribonucleotides</term><term>Poly I-C</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antigens, CD</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Interferon-gamma</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Adjuvants immunologiques</term><term>Imidazoles</term><term>Oligodésoxyribonucléotides</term><term>Poly I-C</term><term>Vaccins antiviraux</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Antigènes CD</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Interféron gamma</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>CD8-Positive T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigène HLA-A2</term><term>Lymphocytes T CD8+</term><term>Vaccins antiviraux</term><term>Virus du SRAS</term><term>Épitopes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD8-Positive T-Lymphocytes</term><term>Epitopes</term><term>HLA-A2 Antigen</term><term>SARS Virus</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Vaccination</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Enzyme-Linked Immunospot Assay</term><term>Flow Cytometry</term><term>Humans</term><term>Immunization, Secondary</term><term>Mice</term><term>Mice, Transgenic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cytométrie en flux</term><term>Humains</term><term>Lymphocytes T CD8+</term><term>Rappel de vaccin</term><term>Souris</term><term>Souris transgéniques</term><term>Test ELISA</term><term>Test ELISpot</term><term>Vaccination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The induction of antigen specific memory CD8<sup>+</sup> T cells in vivo is very important to new vaccines against infectious diseases. In the present study, we aimed to evaluate the immune responses of peptide-specific CD8<sup>+</sup> T cells induced by HLA-A*0201 restricted severe acute respiratory syndrome-associated coronavirus (SARS-CoV) S epitopes plus CpG oligodeoxynucleotide (CpG ODN), PolyI:C and R848 as adjuvants. Furthermore, the generation, distribution and phenotype of long-lasting peptide-specific memory CD8<sup>+</sup> T cells were assessed by ELISA, ELISPOT and flow cytometry. Our results showed that antigen specific CD8<sup>+</sup> T cells were elicited by HLA-A*0201 restricted SARS-CoV S epitopes. Furthermore, the frequency of peptide-specific CD8<sup>+</sup> T cells was dramatically increased after both prime and boost immunization with peptides plus CpG ODN, whereas slight enhancements were induced following boost vaccination with peptides plus PolyI:C or R848. SARS-CoV S peptide-specific IFN-γ<sup>+</sup>CD8<sup>+</sup> T cells were distributed throughout the lymphoid and non-lymphoid tissues. Results also demonstrated that the HLA-A*0201 restricted peptide-specific CD8<sup>+</sup> T cells induced by peptides plus CpG ODN carried a memory cell phenotype with CD45RB<sup>+</sup> and CD62L<sup>−</sup> and possessed long-term survival ability in vivo. Taken together, our results implied that HLA-A*0201 restricted SARS-CoV S epitopes plus CpG ODN might be the superior candidates for SARS vaccine.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name></author><author><name sortKey="Gunther, S" uniqKey="Gunther S">S. Gunther</name></author><author><name sortKey="Preiser, W" uniqKey="Preiser W">W. Preiser</name></author><author><name sortKey="Van Der Werf, S" uniqKey="Van Der Werf S">S. van der Werf</name></author><author><name sortKey="Brodt, H R" uniqKey="Brodt H">H.R. Brodt</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S. 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Basta</name></author><author><name sortKey="Busch, D H" uniqKey="Busch D">D.H. Busch</name></author><author><name sortKey="Gander, B" uniqKey="Gander B">B. Gander</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Salerno Goncalves, R" uniqKey="Salerno Goncalves R">R. Salerno-Goncalves</name></author><author><name sortKey="Sztein, M B" uniqKey="Sztein M">M.B. Sztein</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Wang, Hui" sort="Wang, Hui" uniqKey="Wang H" first="Hui" last="Wang">Hui Wang</name><name sortKey="Wu, Changyou" sort="Wu, Changyou" uniqKey="Wu C" first="Changyou" last="Wu">Changyou Wu</name><name sortKey="Zhao, Kai" sort="Zhao, Kai" uniqKey="Zhao K" first="Kai" last="Zhao">Kai Zhao</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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